Many of these bulletins fix vulnerabilities that could allow remote attackers to take over your computers, so you should apply the updates post haste. I would recommend starting with the Excel patch, which finally fixes a zero day vulnerability reported over a month ago.
Attackers have actively exploited this flaw in the wild, so you’ll want to fix it immediately. Next, install the IE cumulative patch. End users tend to get into a lot of trouble with their web browser, so you should keep IE up to date. Many of the Windows flaws also pose a critical risk, so apply those patches quickly as well. Finally, I’d save the ISA Server update for last. I suspect that few administrators even use this product if they use devices like the Firebox from WatchGuard. WatchGuard Wire: RSS Feed | WatchGuard
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